ABSTRACT
Objective The Toxicology study of Tibetan medicine MNXT granules was observed to provide basis for clinical safe medication.Methods The acute toxicity test in mice was conducted with the oral maximum-tolerated dosage,and then toxicity reaction and death situations in mice at 14d after the intragastric administration (ig) one day at 3 times was observed; Long-term toxic test:the does of MNXT granule 13.23 g/kg · d-1,6.667 g/kg· d-1,3.33 g/kg· d-1 (equivalent 100,50,25 times of the clinical dosage) were continuous administered to medicating groups for 30 days,and blank group was given distilled water instead.The rats'behavior,appearance,food intake,water intake,body weight were observed,and the blood,blood biochemical parameters,the main organ coefficient,anatomical,pathological morphology were determined at 30d after administration and 15d after withdrawal.Results The maximum study medication dose of Tibet an medicine MNXT granule was 39 g/kg (equivalent to 300 times the clinical dose) and the mice had not any adverse reaction.Long-term toxicity test:the rats' blood and blood biochemical parameters,the main organ coefficient,anatomical,pathological morphology had not significant differences compared with the blank grou? during the 30d administration and 15d withdrawal.Conclusion Toxicity of the Tibetan medicine MNXT granules was not observed in acute or long-term toxicity test.